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Article

Quantifying the contribution of dominance deviation effects to complex trait variation in biobank-scale data.

American journal of human genetics - 6 May 2021

Pazokitoroudi Ali, Chiu Alec M, Burch Kathryn S, Pasaniuc Bogdan, Sankararaman Sriram

Abstract excerpt

The proportion of variation in complex traits that can be attributed to non-additive genetic effects has been a topic of intense debate. The availability of biobank-scale datasets of genotype and trait data from unrelated individuals opens up the possibility of obtaining precise estimates of the contribution of non-additive genetic effects. We present an efficient method to estimate the variation in a complex...

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Identifiers

PMID: 33811807
DOI: 10.1016/j.ajhg.2021.03.018
PMCID: PMC8206203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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