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Analysis of genetic dominance in the UK Biobank

2021-08-15

Abstract excerpt

Classical statistical genetic theory defines dominance as a deviation from a purely additive effect. Dominance is well documented in model organisms and plant/animal breeding; outside of rare monogenic traits, however, evidence in humans is limited. We evaluated dominance effects in >1,000 phenotypes in the UK Biobank through GWAS, identifying 175 genome-wide significant loci (P < 4.7 × 10 −11 ). Power to detect...

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Literature Corpus work
a21d8d72-b4ab-5efc-889b-065b6613916c
DOI
10.1101/2021.08.15.456387
Open publication

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Analysis of genetic dominance in the UK BiobankDOI 10.1101/2021.08.15.456387
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