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Article

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals.

American journal of human genetics - 6 May 2021

Hivert Valentin, Sidorenko Julia, Rohart Florian, Goddard Michael E, Yang Jian, Wray Naomi R, Yengo Loic, Visscher Peter M

Abstract excerpt

Non-additive genetic variance for complex traits is traditionally estimated from data on relatives. It is notoriously difficult to estimate without bias in non-laboratory species, including humans, because of possible confounding with environmental covariance among relatives. In principle, non-additive variance attributable to common DNA variants can be estimated from a random sample of unrelated individuals with...

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Identifiers

PMID: 33811805
DOI: 10.1016/j.ajhg.2021.02.014
PMCID: PMC8205999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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