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Article

Estimating the mode of inheritance in genetic association studies of qualitative traits based on the degree of dominance index.

BMC medical research methodology - 21 Dec 2011

Zintzaras Elias, Santos Mauro

Abstract excerpt

BACKGROUND: The biological justification for the choice of the genetic mode in genetic association studies (GAS) is seldom available. Then, the mode of inheritance is approximated by investigating a number of non-orthogonal genetic contrasts making the interpretation of results difficult. METHODS: We propose to define the mode of inheritance by the significance of the deviance of the co-dominant contrast and the...

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Identifiers

PMID: 22188898
DOI: 10.1186/1471-2288-11-171
PMCID: PMC3299619

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Source receipt: pubmed, retrieved 7 Sept 2026.

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