Article
Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance.
American journal of physiology. Heart and circulatory physiology - 15 Mar 2015
Hoffman Nicholas E, Miller Barbara A, Wang JuFang, Elrod John W, Rajan Sudasan, Gao Erhe, Song Jianliang, Zhang Xue-Qian, Hirschler-Laszkiewicz Iwona, Shanmughapriya Santhanam, Koch Walter J, Feldman Arthur M, Madesh Muniswamy, Cheung Joseph Y
Abstract excerpt
Ubiquitously expressed Trpm2 channel limits oxidative stress and preserves mitochondrial function. We first demonstrated that intracellular Ca(2+) concentration increase after Trpm2 activation was due to direct Ca(2+) influx and not indirectly via reverse Na(+)/Ca(2+) exchange. To elucidate whether Ca(2+) entry via Trpm2 is required to maintain cellular bioenergetics, we injected adenovirus expressing green...
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