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Article

KATP channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart.

American journal of physiology. Heart and circulatory physiology - 1 Apr 2007

Gumina Richard J, O'Cochlain D Fearghas, Kurtz Christopher E, Bast Peter, Pucar Darko, Mishra Prasanna, Miki Takashi, Seino Susumu, Macura Slobodan, Terzic Andre

Abstract excerpt

Gene knockout of the KCNJ11-encoded Kir6.2 ATP-sensitive K(+) (K(ATP)) channel implicates this stress-response element in the safeguard of cardiac homeostasis under imposed demand. K(ATP) channels are abundant in ventricular sarcolemma, where subunit expression appears to vary between the sexes. A limitation, however, in establishing the full significance of K(ATP) channels in the intact organism has been the...

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Source

Identifiers

PMID: 17189350
DOI: 10.1152/ajpheart.01305.2006

Genes

KCNJ11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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