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Article

Preservation of cardiac function by prolonged action potentials in mice deficient of KChIP2

9 Jun 2015

Abstract excerpt

Inherited ion channelopathies and electrical remodeling in heart disease alter the cardiac action potential with important consequences for excitation-contraction coupling. Potassium channel-interacting protein 2 (KChIP2) is reduced in heart failure and interacts under physiological conditions with both Kv4 to conduct the fast-recovering transient outward K(+) current (Ito,f) and with CaV1.2 to mediate the inward...

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Identifiers

PMID: 26055791
DOI: 10.1152/ajpheart.00166.2015

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Preservation of cardiac function by prolonged action potentials in mice deficient of KChIP2PMID 26055791Read ↗

Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice.Semantic proximity Read ↗

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