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Article

Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium.

Journal of the American Heart Association - 21 Jul 2015

Kiermayer Claudia, Northrup Emily, Schrewe Anja, Walch Axel, de Angelis Martin Hrabe, Schoensiegel Frank, Zischka Hans, Prehn Cornelia, Adamski Jerzy, Bekeredjian Raffi, Ivandic Boris, Kupatt Christian, Brielmeier Markus

Abstract excerpt

BACKGROUND: Ubiquitous deletion of thioredoxin reductase 2 (Txnrd2) in mice is embryonically lethal and associated with abnormal heart development, while constitutive, heart-specific Txnrd2 inactivation leads to dilated cardiomyopathy and perinatal death. The significance of Txnrd2 in aging cardiomyocytes, however, has not yet been examined. METHODS AND RESULTS: The tamoxifen-inducible heart-specific...

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Share to Hypoxia-Inducible Factor 1, alpha Subunit
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26199228
DOI: 10.1161/JAHA.115.002153
PMCID: PMC4608093

Genes

LAMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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