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Disrupting the Feed-Forward Cycle of RyR1 Ca <sup>2+</sup> Leak and Oxidative Stress Mitigates Doxorubicin-Induced Skeletal Myopathy

2025-11-13

Abstract excerpt

Doxorubicin (DOX), a highly effective and widely used chemotherapeutic agent used to treat various types of cancer. Unfortunately, DOX also has some undesirable and off-target effects, particularly debilitating muscle weakness and fatigue. The mechanism behind this DOX-induced skeletal myotoxicity (DISM) remains unclear. Here, we show that acute DOX exposure, at clinically relevant concentrations, impairs isometri...

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Identifiers and source

Literature Corpus work
49a525cd-c76e-5351-8589-cf7fe52faf0d
DOI
10.1101/2025.11.12.688073
Open publication

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Disrupting the Feed-Forward Cycle of RyR1 Ca <sup>2+</sup> Leak and Oxidative Stress Mitigates Doxorubicin-Induced Skeletal MyopathyDOI 10.1101/2025.11.12.688073
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