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Article

Mitochondrial calcium overload is a key determinant in heart failure.

Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2015

Santulli Gaetano, Xie Wenjun, Reiken Steven R, Marks Andrew R

Abstract excerpt

Calcium (Ca2+) released from the sarcoplasmic reticulum (SR) is crucial for excitation-contraction (E-C) coupling. Mitochondria, the major source of energy, in the form of ATP, required for cardiac contractility, are closely interconnected with the SR, and Ca2+ is essential for optimal function of these organelles. However, Ca2+ accumulation can impair mitochondrial function, leading to reduced ATP production and...

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Identifiers

PMID: 26217001
DOI: 10.1073/pnas.1513047112
PMCID: PMC4568687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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