Article
Overexpression of SUR2A generates a cardiac phenotype resistant to ischemia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2006
Du Qingyou, Jovanović Sofija, Clelland Allyson, Sukhodub Andrey, Budas Grant, Phelan Karen, Murray-Tait Victoria, Malone Lorraine, Jovanović Aleksandar
Abstract excerpt
ATP-sensitive K+ (K(ATP)) channels are present in the sarcolemma of cardiac myocytes where they link membrane excitability with the cellular bioenergetic state. These channels are in vivo composed of Kir6.2, a pore-forming subunit, SUR2A, a regulatory subunit, and at least four accessory proteins. In the present study, real-time RT-PCR has demonstrated that of all six sarcolemmal K(ATP) channel-forming proteins,...
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