Article
The mitochondrial bioenergetic phenotype for protection from cardiac ischemia in SUR2 mutant mice.
American journal of physiology. Heart and circulatory physiology - 1 Dec 2010
Aggarwal Nitin T, Pravdic Danijel, McNally Elizabeth M, Bosnjak Zeljko J, Shi Nian-Qing, Makielski Jonathan C
Abstract excerpt
The sulfonylurea receptor-2 (SUR2) is a subunit of ATP-sensitive potassium channels (K(ATP)) in heart. Mice with the SUR2 gene disrupted (SUR2m) are constitutively protected from ischemia-reperfusion (I/R) cardiac injury. This was surprising because K(ATP), either sarcolemmal or mitochondrial or both, are thought to be important for cardioprotection. We hypothesized that SUR2m mice have an altered mitochondrial...
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