Article
Cardiomyocyte ATP production, metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in vivo.
The Journal of biological chemistry - 28 Jun 2013
Bround Michael J, Wambolt Rich, Luciani Dan S, Kulpa Jerzy E, Rodrigues Brian, Brownsey Roger W, Allard Michael F, Johnson James D
Abstract excerpt
Ca(2+) fluxes between adjacent organelles are thought to control many cellular processes, including metabolism and cell survival. In vitro evidence has been presented that constitutive Ca(2+) flux from intracellular stores into mitochondria is required for basal cellular metabolism, but these observations have not been made in vivo. We report that controlled in vivo depletion of cardiac RYR2, using a conditional...
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