Article
Cardioprotection via preserved mitochondrial structure and function in the mPer2-mutant mouse myocardium.
American journal of physiology. Heart and circulatory physiology - 15 Aug 2013
Virag Jitka A I, Anderson Ethan J, Kent Susan D, Blanton Harrison D, Johnson Tracy L, Moukdar Fatiha, DeAntonio Jonathan H, Thayne Kathleen, Ding Jian M, Lust Robert M
Abstract excerpt
We have previously shown that myocardial infarct size in nonreperfused hearts of mice with a functional deletion of the circadian rhythm gene mPer2 (mPer2-M) was reduced by 43%. We hypothesized that acute ischemia-reperfusion injury (I/R = 30 min I/2 h R) would also be reduced in these mice and that ischemic preconditioning (IPC) (3 × 5 min cycles) before I/R, which enhances protection in wild-type (WT) hearts,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.