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Mitochondrial reactive oxygen species cause arrhythmias in hypertrophic cardiomyopathy

2024-10-03

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and caused by genetic variants that often increase sarcomeric Ca 2+ sensitivity. While Ca 2+ sensitization explains diastolic dysfunction, the genesis of ventricular arrhythmias is unresolved. Here, we show that HCM mutations or pharmacological interventions that increase myofilament Ca 2+ sensitivity generate bioenergetic mismatch a...

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Identifiers and source

Literature Corpus work
9c205271-6db1-5f6d-a8f9-8e87edfb1c5c
DOI
10.1101/2024.10.02.616214
Open publication

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Mitochondrial reactive oxygen species cause arrhythmias in hypertrophic cardiomyopathyDOI 10.1101/2024.10.02.616214
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