Article
Cys340Ser Mutation Abolishing S-Nitrosylation Drives GRK2 Mitochondrial Localization and Dysfunction.
Cells - 4 Mar 2026
Kayki Mutlu Gizem, Kereliuk Stephanie M, Hoteit Maya, Chuprun J Kurt, Mendes Umur, Olgar Yusuf, Koch Walter J
Abstract excerpt
In cardiac pathologies, levels of G protein-coupled receptor kinase 2 (GRK2)-which is involved in receptor desensitization and internalization-are elevated. Beyond these receptor-mediated effects, GRK2 also localizes to mitochondria, where it contributes to pathology. GRK2's activity can be inhibited via S-nitrosylation at Cysteine 340, a post-translational modification mediated by both endogenous and exogenous...
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