Article

β <sub>2</sub> -Adrenergic Signaling Switches from Cardioprotective to Cardiotoxic in Acute vs. Chronic Oxidative Stress

2026-04-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND AND PURPOSE</h4> β-adrenergic receptors (AR) regulate both cardiac function and remodeling. Many studies suggest that, in addition to their effects on heart rate and contractility, β 1 -ARs mediate cardiotoxic signaling, whereas β 2 -ARs are generally cardioprotective. However, there is conflicting data on the role of β 2 -ARs, differing dependent on the nature of the stress....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f3564008-ccf4-54c8-8e60-cd5220bbf2f3
DOI: 10.64898/2026.04.22.720269

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

β <sub>2</sub> -Adrenergic Signaling Switches from Cardioprotective to Cardiotoxic in Acute vs. Chronic Oxidative StressDOI 10.64898/2026.04.22.720269Read

Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization.Semantic proximity Read

Mechanisms of Disease: β-adrenergic receptors—alterations in signal transduction and pharmacogenomics in heart failureSemantic proximity Read

Psychosocial stress exacerbates doxorubicin-induced cardiotoxicity in adult C57BL/6N miceSemantic proximity Read

A NRF2/β3-adrenoreceptor axis drives a sustained antioxidant and metabolic rewiring through the pentose-phosphate pathway to alleviate cardiac stressSemantic proximity Read

Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genesSemantic proximity Read

Genetic and phenotypic targeting of beta-adrenergic signaling in heart failure.Semantic proximity Read

Inhibition of late INa prevents pathological hyperactivation of CaMKIIδ in a murine model of acute Doxorubicin-related cardiocellular toxicitySemantic proximity Read

Differential Impact of Doxorubicin Dose on Cell Death and Autophagy Pathways during Acute CardiotoxicitySemantic proximity Read

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies.Semantic proximity Read

Substrain-Dependent Differences in Doxorubicin-Induced Cardiotoxicity in Adult C57BL/6 Mice.Semantic proximity Read

p38β/MAPK11 Deficiency Exacerbates Cardiac Structural and Electrophysiological Remodeling and Contributes to Immune Dysregulation in the Aging HeartSemantic proximity Read

Cardiac Oxidative Signaling and Physiological Hypertrophy in the Na/K-ATPase α1s/sα2s/s Mouse Model of High Affinity for Cardiotonic Steroids.Semantic proximity Read