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Article

ABCA1 and HDL3 are required to modulate smooth muscle cells phenotypic switch after cholesterol loading.

Atherosclerosis - 1 Nov 2017

Castiglioni Silvia, Monti Matteo, Arnaboldi Lorenzo, Canavesi Monica, Ainis Buscherini Giuditta, Calabresi Laura, Corsini Alberto, Bellosta Stefano

Abstract excerpt

BACKGROUND AND AIMS: Cholesterol-loaded smooth muscle cells (SMCs) modify their phenotypic behavior becoming foam cells. To characterize the role of ABCA1 and HDL3 in this process, we evaluated HDL3 effects on cholesterol-induced phenotypic changes in SMCs expressing or not ABCA1. METHODS: SMCs, isolated from the aortae of wild-type (WT) and Abca1 knock-out (KO) mice, were cholesterol-loaded using a...

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Source

Identifiers

PMID: 28946038
DOI: 10.1016/j.atherosclerosis.2017.09.012

Genes

ABCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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