Article
Integrative pathway dissection of molecular mechanisms of moxLDL-induced vascular smooth muscle phenotype transformation.
BMC cardiovascular disorders - 16 Jan 2013
Karagiannis George S, Weile Jochen, Bader Gary D, Minta Joe
Abstract excerpt
BACKGROUND: Atherosclerosis (AT) is a chronic inflammatory disease characterized by the accumulation of inflammatory cells, lipoproteins and fibrous tissue in the walls of arteries. AT is the primary cause of heart attacks and stroke and is the leading cause of death in Western countries. To date, the pathogenesis of AT is not well-defined. Studies have shown that the dedifferentiation of contractile and...
Topics
- Atherosclerosis
- Cell Dedifferentiation
- Cells, Cultured
- Coronary Vessels
- Gene Expression Profiling
- Gene Expression Regulation
- Gene Regulatory Networks
- Genotype
- Humans
- Lipoproteins, LDL
- Muscle, Smooth, Vascular