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Article

Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster.

The Journal of clinical investigation - 1 Sept 2009

Boettger Thomas, Beetz Nadine, Kostin Sawa, Schneider Johanna, Krüger Marcus, Hein Lutz, Braun Thomas

Abstract excerpt

VSMCs respond to changes in the local environment by adjusting their phenotype from contractile to synthetic, a phenomenon known as phenotypic modulation or switching. Failure of VSMCs to acquire and maintain the contractile phenotype plays a key role in a number of major human diseases, including arteriosclerosis. Although several regulatory circuits that control differentiation of SMCs have been identified, the...

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Identifiers

PMID: 19690389
DOI: 10.1172/JCI38864
PMCID: PMC2735940

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster.PMID 19690389Read ↗

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