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Article

Prediction of resistance development against drug combinations by collateral responses to component drugs.

Science translational medicine - 12 Nov 2014

Munck Christian, Gumpert Heidi K, Wallin Annika I Nilsson, Wang Harris H, Sommer Morten O A

Abstract excerpt

Resistance arises quickly during chemotherapeutic selection and is particularly problematic during long-term treatment regimens such as those for tuberculosis, HIV infections, or cancer. Although drug combination therapy reduces the evolution of drug resistance, drug pairs vary in their ability to do so. Thus, predictive models are needed to rationally design resistance-limiting therapeutic regimens. Using...

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Identifiers

PMID: 25391482
DOI: 10.1126/scitranslmed.3009940
PMCID: PMC4503331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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