Article

Genetic determinants of antibiotic resistance and the evolution of trade-offs during adaptation in a single patient

2021-10-07

Abstract excerpt

The processes by which pathogens evolve within single hosts dictate the efficacy of treatment strategies designed to slow antibiotic resistance evolution and influence the population-wide resistance levels. The aim of this study is to describe the underlying genetic and phenotypic changes leading to antibiotic resistance within a single patient who died as resistance evolved to available antibiotics. We assess whe...

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Literature Corpus work: 397d1a54-d526-5f27-85a5-16994f021386
DOI: 10.1101/2021.10.06.463321

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