Article
Acceleration and suppression of resistance development by antibiotic combinations.
BMC genomics - 26 Apr 2017
Suzuki Shingo, Horinouchi Takaaki, Furusawa Chikara
Abstract excerpt
BACKGROUND: The emergence and spread of antibiotic resistance in bacteria is becoming a global public health problem. Combination therapy, i.e., the simultaneous use of multiple antibiotics, is used for long-term treatment to suppress the emergence of resistant strains. However, the effect of the combinatorial use of multiple drugs on the development of resistance remains elusive, especially in a quantitative...
Topics
- Anti-Bacterial Agents
- Directed Molecular Evolution
- Drug Interactions
- Drug Resistance, Bacterial
- Drug Resistance, Multiple, Bacterial
- Epistasis, Genetic
- Escherichia coli
- Mutation