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Article

Accelerated evolution of resistance in multidrug environments

8 Sept 2008

Abstract excerpt

The emergence of resistance during multidrug chemotherapy impedes the treatment of many human diseases, including malaria, TB, HIV, and cancer. Although certain combination therapies have long been known to be more effective in curing patients than single drugs, the impact of such treatments on the evolution of drug resistance is unclear. In particular, very little is known about how the evolution of resistance...

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PMID: 18779569
DOI: 10.1073/pnas.0805965105

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