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Article

Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli.

Nature communications - 10 Sept 2018

Podnecky Nicole L, Fredheim Elizabeth G A, Kloos Julia, Sørum Vidar, Primicerio Raul, Roberts Adam P, Rozen Daniel E, Samuelsen Ørjan, Johnsen Pål J

Abstract excerpt

There is urgent need to develop novel treatment strategies to reduce antimicrobial resistance. Collateral sensitivity (CS), where resistance to one antimicrobial increases susceptibility to other drugs, might enable selection against resistance during treatment. However, the success of this approach would depend on the conservation of CS networks across genetically diverse bacterial strains. Here, we examine CS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30202004
DOI: 10.1038/s41467-018-06143-y
PMCID: PMC6131505

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