Article
Mutational basis of ceftazidime-borrelidin A collateral sensitivity in Escherichia coli.
G3 (Bethesda, Md.) - 6 May 2026
Phillips Laura L, Carrasco Arianna, Weiss Jonathan, Liu Dennis Y, Linington Roger G, Wong Alex
Abstract excerpt
The rapid emergence of antimicrobial resistance in bacterial pathogens threatens the efficacy of nearly all available antibiotics. One evolution-informed strategy to limit the emergence of resistance is the exploitation of collateral sensitivity, whereby resistance to one compound results in increased sensitivity to another. Here, we investigate the collateral sensitivity relationship between the cephalosporin...
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