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Article

Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance.

PLoS biology - 1 Oct 2019

Maltas Jeff, Wood Kevin B

Abstract excerpt

Evolved resistance to one antibiotic may be associated with "collateral" sensitivity to other drugs. Here, we provide an extensive quantitative characterization of collateral effects in Enterococcus faecalis, a gram-positive opportunistic pathogen. By combining parallel experimental evolution with high-throughput dose-response measurements, we measure phenotypic profiles of collateral sensitivity and resistance...

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Source

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Identifiers

PMID: 31652256
DOI: 10.1371/journal.pbio.3000515
PMCID: PMC6834293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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