Article
Alternative Evolutionary Paths to Bacterial Antibiotic Resistance Cause Distinct Collateral Effects.
Molecular biology and evolution - 1 Sept 2017
Barbosa Camilo, Trebosc Vincent, Kemmer Christian, Rosenstiel Philip, Beardmore Robert, Schulenburg Hinrich, Jansen Gunther
Abstract excerpt
When bacteria evolve resistance against a particular antibiotic, they may simultaneously gain increased sensitivity against a second one. Such collateral sensitivity may be exploited to develop novel, sustainable antibiotic treatment strategies aimed at containing the current, dramatic spread of drug resistance. To date, the presence and molecular basis of collateral sensitivity has only been studied in few...
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