Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Use of collateral sensitivity networks to design drug cycling protocols that avoid resistance development.

Science translational medicine - 25 Sept 2013

Imamovic Lejla, Sommer Morten O A

Abstract excerpt

New drug deployment strategies are imperative to address the problem of drug resistance, which is limiting the management of infectious diseases and cancers. We evolved resistance in Escherichia coli toward 23 drugs used clinically for treating bacterial infections and mapped the resulting collateral sensitivity and resistance profiles, revealing a complex collateral sensitivity network. On the basis of these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Drug Design
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Kinetics

Share to Microbial Sensitivity Tests

Share to Microbial Viability

Share to Mutation

Source

Identifiers

PMID: 24068739
DOI: 10.1126/scitranslmed.3006609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Use of collateral sensitivity networks to design drug cycling protocols that avoid resistance development.PMID 24068739Read ↗

Evolutionary drivers of divergent collateral sensitivity responses during antibiotic therapy.Semantic proximity Read ↗

Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance.Semantic proximity Read ↗

Design principles of collateral sensitivity-based dosing strategies.Semantic proximity Read ↗

Scheduling collateral sensitivity‐based cycling therapies toward eradication of drug‐resistant infectionsSemantic proximity Read ↗

Evolutionary trajectories determine the feasibility of collateral sensitivity based antibiotic treatment strategies in critical bacterial pathogensSemantic proximity Read ↗

Divergent spontaneous antibiotic-resistance evolution confers reciprocal and exploitable collateral sensitivity effectsSemantic proximity Read ↗

Conserved collateral susceptibility networks in diverse clinical strains of <i>Escherichia coli</i>Semantic proximity Read ↗

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical geneticsSemantic proximity Read ↗

Prediction of resistance development against drug combinations by collateral responses to component drugs.Semantic proximity Read ↗

Navigating collateral sensitivity: insights into the mechanisms and applications of antibiotic resistance trade-offsSemantic proximity Read ↗

Large scale laboratory evolution uncovers clinically relevant collateral antibiotic sensitivitySemantic proximity Read ↗

Collateral sensitivity of antibiotic-resistant microbes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.