Article

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics

2024-01-27

Abstract excerpt

By acquiring or evolving resistance to one antibiotic, bacteria can become resistant to a second one, due to shared underlying mechanisms. This is called cross-resistance (XR) and further limits therapeutic choices. The opposite scenario, in which initial resistance leads to sensitivity to a second antibiotic, is termed collateral sensitivity (CS) and can inform cycling or combinatorial treatments. Despite their c...

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Literature Corpus work: 2409cdd3-db2b-5dd2-957d-4dba3c414686
DOI: 10.1101/2024.01.25.576750

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