Article
Collateral Resistance and Sensitivity Modulate Evolution of High-Level Resistance to Drug Combination Treatment in Staphylococcus aureus.
Molecular biology and evolution - 1 May 2015
Rodriguez de Evgrafov Mari, Gumpert Heidi, Munck Christian, Thomsen Thomas T, Sommer Morten O A
Abstract excerpt
As drug-resistant pathogens continue to emerge, combination therapy will increasingly be relied upon to treat infections and to help combat further development of multidrug resistance. At present a dichotomy exists between clinical practice, which favors therapeutically synergistic combinations, and the scientific model emerging from in vitro experimental work, which maintains that this interaction provides...
Topics
- Drug Combinations
- Drug Resistance, Bacterial
- Evolution, Molecular
- Humans
- Mutation
- Staphylococcal Infections
- Staphylococcus aureus