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Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes

21 Oct 2014

Abstract excerpt

T follicular helper (Tfh) cells are a subset of CD4(+) T helper cells that migrate into germinal centers and promote B-cell maturation into memory B and plasma cells. Tfh cells are necessary for promotion of protective humoral immunity following pathogen challenge, but when aberrantly regulated, drive pathogenic antibody formation in autoimmunity and undergo neoplastic transformation in angioimmunoblastic T-cell...

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PMID: 25331115
DOI: 10.1182/blood-2014-06-582700

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