Article

Human follicular helper T cell promoter connectomes reveal novel genes and regulatory elements at SLE GWAS loci

2019-12-21

Abstract excerpt

<h4>ABSTRACT</h4> Systemic lupus erythematosus (SLE) is a complex inflammatory disease mediated by autoreactive antibodies that damages multiple tissues in children and adults. Genome-wide association studies (GWAS) have statistically implicated hundreds of loci in the susceptibility to human disease, including SLE, but the majority have failed to identify the causal variants or the effector genes. As a physicoch...

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Literature Corpus work: 71a902e7-b172-50d9-b957-50bb40eec22c
DOI: 10.1101/2019.12.20.885426

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