An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases.

doi:10.1126/science.add8394

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Article

An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases.

Science (New York, N.Y.) - 5 Jul 2024

Oguchi Akiko, Suzuki Akari, Komatsu Shuichiro, Yoshitomi Hiroyuki, Bhagat Shruti, Son Raku, Bonnal Raoul Jean Pierre, Kojima Shohei, Koido Masaru, Takeuchi Kazuhiro, Myouzen Keiko, Inoue Gyo, Hirai Tomoya, Sano Hiromi, Takegami Yujiro, Kanemaru Ai, Yamaguchi Itaru, Ishikawa Yuki, Tanaka Nao, Hirabayashi Shigeki, Konishi Riyo, Sekito Sho, Inoue Takahiro, Kere Juha, Takeda Shunichi, Takaori-Kondo Akifumi, Endo Itaru, Kawaoka Shinpei, Kawaji Hideya, Ishigaki Kazuyoshi, Ueno Hideki, Hayashizaki Yoshihide, Pagani Massimiliano, Carninci Piero, Yanagita Motoko, Parrish Nicholas, Terao Chikashi, Yamamoto Kazuhiko, Murakawa Yasuhiro

Abstract excerpt

Transcribed enhancer maps can reveal nuclear interactions underpinning each cell type and connect specific cell types to diseases. Using a 5' single-cell RNA sequencing approach, we defined transcription start sites of enhancer RNAs and other classes of coding and noncoding RNAs in human CD4+ T cells, revealing cellular heterogeneity and differentiation trajectories. Integration of these datasets with single-cell...

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Identifiers

PMID: 38963856
DOI: 10.1126/science.add8394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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