Article

Network-based integration of epigenetic landscapes unveils molecular programs underlying human T follicular helper cell differentiation

2021-05-21

Abstract excerpt

T follicular helper (Tfh) cells play a critical role in T-dependent humoral immune responses. While genetic programs controlling Tfh cell differentiation have been extensively studied using murine models, studies in humans have been hampered by the lack of a robust in vitro differentiation system for Tfh cells. We characterized epigenomic landscapes across stages of Tfh cell differentiation in a healthy human ton...

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Literature Corpus work: 1fff891e-9dbb-5b85-bb86-c053e87db7bd
DOI: 10.1101/2021.05.19.444859

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