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Multimodal analysis defines <i>GNG4</i> as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans

2025-12-13

Abstract excerpt

CD4 T follicular helper (Tfh) cells coordinate humoral immune responses within germinal centers (GC) of lymphoid tissue. Despite their critical roles in vaccination and autoimmunity, the gene expression programs that define functionally distinct human Tfh states— and the molecular pathways engaged by Tfh positioned within the GC niche—remain incompletely understood. This gap has limited translational efforts to mo...

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Literature Corpus work
86cb4e90-658b-5f5a-a689-a093354a80c3
DOI
10.64898/2025.12.10.693235
Open publication

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Multimodal analysis defines <i>GNG4</i> as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humansDOI 10.64898/2025.12.10.693235
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