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Article

In Situ Characterization of Follicular Helper CD4 T Cells Using Multiplexed Imaging.

Frontiers in immunology - 1 Jan 2020

Ioannidou Kalliopi, Ndiaye Daba-Rokhya, Noto Alessandra, Fenwick Craig, Fortis Sotirios P, Pantaleo Giuseppe, Petrovas Constantinos, de Leval Laurence

Abstract excerpt

Follicular helper CD4 T (Tfh) cells play an essential role in the formation of germinal centers (GCs), where mature B cells proliferate, differentiate, and provide long-term protective humoral responses. Despite the extensive phenotypic characterization and identification of human Tfh cell subsets, their spatial positioning at tissue level is not well understood. Here, we describe a quantitative multiplexed...

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Identifiers

PMID: 33633728
DOI: 10.3389/fimmu.2020.607626
PMCID: PMC7901994

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