Article

Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci

2021-03-17

Abstract excerpt

The germinal center (GC) response is critical for both effective adaptive immunity and establishing peripheral tolerance by limiting auto-reactive B cells. Dysfunction in these processes can lead to defects in immune response to pathogens or contribute to autoimmune disease. To understand the gene regulatory principles underlying the GC response, we generated a single-cell transcriptomic and epigenomic atlas of th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd122fe8-4382-5049-9d8d-90b69e2c5522
DOI: 10.1101/2021.03.16.435578

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk lociDOI 10.1101/2021.03.16.435578Read

Multimodal analysis defines <i>GNG4</i> as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humansSemantic proximity Read

Network-based integration of epigenetic landscapes unveils molecular programs underlying human T follicular helper cell differentiationSemantic proximity Read

Tonsillar expression quantitative trait loci verify and expand genetic contributors to childhood atopic diseasesSemantic proximity Read

An Atlas of Cells in the Human TonsilSemantic proximity Read

A multi-omics resource of B cell activation reveals genetic mechanisms for immune-mediated diseasesSemantic proximity Read

Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease.Semantic proximity Read

Human follicular helper T cell promoter connectomes reveal novel genes and regulatory elements at SLE GWAS lociSemantic proximity Read

IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpointsSemantic proximity Read

Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases.Semantic proximity Read

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elementsSemantic proximity Read

Population-scale multiome immune cell atlas reveals complex disease driversSemantic proximity Read

Distinct stage-specific transcriptional states of B cells in human tonsillar tissueSemantic proximity Read