Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells.

Nature communications - 3 Jul 2020

Su Chun, Johnson Matthew E, Torres Annabel, Thomas Rajan M, Manduchi Elisabetta, Sharma Prabhat, Mehra Parul, Le Coz Carole, Leonard Michelle E, Lu Sumei, Hodge Kenyaita M, Chesi Alessandra, Pippin James, Romberg Neil, Grant Struan F A, Wells Andrew D

Abstract excerpt

Systemic lupus erythematosus (SLE) is mediated by autoreactive antibodies that damage multiple tissues. Genome-wide association studies (GWAS) link >60 loci with SLE risk, but the causal variants and effector genes are largely unknown. We generated high-resolution spatial maps of SLE variant accessibility and gene connectivity in human follicular helper T cells (TFH), a cell type required for anti-nuclear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Jurkat Cells

Share to Lupus Erythematosus, Systemic

Share to Protein Serine-Threonine Kinases

Share to Proto-Oncogene Proteins c-bcl-6

Share to RNA Interference

Share to T-Lymphocytes, Helper-Inducer

Source

Open in PubMed Open full text

Identifiers

PMID: 32620744
DOI: 10.1038/s41467-020-17089-5
PMCID: PMC7335045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells.PMID 32620744Read ↗

Human follicular helper T cell promoter connectomes reveal novel genes and regulatory elements at SLE GWAS lociSemantic proximity Read ↗

A multilayered post-GWAS analysis pipeline defines functional variants and target genes for systemic lupus erythematosus (SLE)Semantic proximity Read ↗

A Multilayered Post-Genome-Wide Association Study Analysis Pipeline Defines Functional Variants and Target Genes for Systemic Lupus Erythematosus.Semantic proximity Read ↗

3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibilitySemantic proximity Read ↗

3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility.Semantic proximity Read ↗

High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry.Semantic proximity Read ↗

Variant-to-function mapping in lupus links <i>IL12A</i> to the expansion of disease-associated B cells with a cytotoxic programSemantic proximity Read ↗

Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci.Semantic proximity Read ↗

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elementsSemantic proximity Read ↗

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production.Semantic proximity Read ↗

Discovery and Functional Characterization of Two Regulatory Variants Underlying Lupus Susceptibility at 2p13.1.Semantic proximity Read ↗

Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.