Article

Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating T cells

2022-03-18

Abstract excerpt

Despite extensive studies on the chromatin landscape of exhausted T cells, the transcriptional wiring underlying the heterogeneous functional and dysfunctional states of human tumor-infiltrating lymphocytes (TILs) is incompletely understood. Here, we identify tissue-specific and general gene-regulatory landscapes in the wide breadth of CD8 + TIL functional states covering four cancer entities using single-cell ch...

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Literature Corpus work: 373780da-05eb-5888-9c93-565e1300a4db
DOI: 10.1101/2022.03.16.484513

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