Article
Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization.
Immunity - 27 Jun 2013
Hawkins R David, Larjo Antti, Tripathi Subhash K, Wagner Ulrich, Luu Ying, Lönnberg Tapio, Raghav Sunil K, Lee Leonard K, Lund Riikka, Ren Bing, Lähdesmäki Harri, Lahesmaa Riitta
Abstract excerpt
Naive CD4⁺ T cells can differentiate into specific helper and regulatory T cell lineages in order to combat infection and disease. The correct response to cytokines and a controlled balance of these populations is critical for the immune system and the avoidance of autoimmune disorders. To investigate how early cell-fate commitment is regulated, we generated the first human genome-wide maps of histone...
Topics
- Cell Differentiation
- Cell Lineage
- Chromatin
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Histones
- Humans
- Immune System Diseases
- Polymorphism, Single Nucleotide