Article

Integration of genetic and epigenetic data pinpoints autoimmune specific remodelling of enhancer landscape in CD4+ T cells

2024-01-15

Abstract excerpt

<h4>Summary</h4> CD4+ T cells play a crucial role in adaptive immune responses and have been implicated in the pathogenesis of autoimmune diseases (ADs). Despite numerous studies, the molecular mechanisms underlying T cell dysregulation in ADs remain incompletely understood. Here, we used transcriptomic and epigenomic data from CD4+ T cells of healthy donors and patients with systemic lupus erythematosus (SLE), p...

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Literature Corpus work: 361b04fa-b0d7-56fa-a170-2e3e89bc9c30
DOI: 10.1101/2024.01.11.575022

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