Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kinetic competition during the transcription cycle results in stochastic RNA processing.

eLife - 1 Oct 2014

Coulon Antoine, Ferguson Matthew L, de Turris Valeria, Palangat Murali, Chow Carson C, Larson Daniel R

Abstract excerpt

Synthesis of mRNA in eukaryotes involves the coordinated action of many enzymatic processes, including initiation, elongation, splicing, and cleavage. Kinetic competition between these processes has been proposed to determine RNA fate, yet such coupling has never been observed in vivo on single transcripts. In this study, we use dual-color single-molecule RNA imaging in living human cells to construct a complete...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Globins
Share to Computer Systems
Share to Diffusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutant Proteins

Share to Ribonucleoproteins

Share to RNA Processing, Post-Transcriptional

Share to Splicing Factor U2AF

Share to Stochastic Processes

Source

Open in PubMed Open full text

Identifiers

PMID: 25271374
DOI: 10.7554/eLife.03939
PMCID: PMC4210818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kinetic competition during the transcription cycle results in stochastic RNA processing.PMID 25271374Read ↗

CAR-SPLASH identifies nascent pre-mRNA structures implicated in kinetic coupling and alternative splicingSemantic proximity Read ↗

Human co-transcriptional splicing kinetics and coordination revealed by direct nascent RNA sequencingSemantic proximity Read ↗

Single-molecule imaging of transcriptionally coupled and uncoupled splicing.Semantic proximity Read ↗

Genomic sequences and RNA binding proteins predict RNA splicing kinetics in various single-cell contextsSemantic proximity Read ↗

"Nought may endure but mutability": spliceosome dynamics and the regulation of splicing.Semantic proximity Read ↗

Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate.Semantic proximity Read ↗

Single Molecule Cluster Analysis dissects splicing pathway conformational dynamics.Semantic proximity Read ↗

Visualizing alternative mRNA splicing in live mammalian cells with the Riboglow-FLIM sensorSemantic proximity Read ↗

Splicing to keep splicing: A feedback system for cellular homeostasis and state transitionSemantic proximity Read ↗

Co-transcriptional splicing regulates 3’ end cleavage during mammalian erythropoiesisSemantic proximity Read ↗

Computational design and interpretation of single-RNA translation experimentsSemantic proximity Read ↗

Dynamic transcription pre-initiation complex assembly governs initiation efficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.