Article

CAR-SPLASH identifies nascent pre-mRNA structures implicated in kinetic coupling and alternative splicing

2025-03-06

Abstract excerpt

Pre-mRNA splicing is kinetically coupled to transcription as shown by the widespread effects of transcription speed on alternative splicing outcomes. The molecular basis for such kinetic coupling is incompletely understood, but one potential mechanism is through elongation rate dependent alternative folding pathways of the nascent pre-mRNA. To search for RNA structures in nascent pre-mRNA, we modified SPLASH (1) (...

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Literature Corpus work: db0c4d19-0f04-5d51-bcca-d9384e312a24
DOI: 10.1101/2025.03.02.641068

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