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Splicing to keep splicing: A feedback system for cellular homeostasis and state transition

1 Jun 2025

Abstract excerpt

BACKGROUND: Alternative splicing (AS) plays a crucial role in regulating gene expression and governing proteomic diversity by generating multiple protein isoforms from a single gene. Increasing evidence has highlighted the regulation for pre-mRNA splicing of the splicing factors (SFs). This review aims to examine featured mechanisms and examples of SF regulation by AS, focusing on paradigmatic feedback loops and...

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PMID: 40538061
DOI: 10.1002/ctm2.70369

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