Article

Computational design and interpretation of single-RNA translation experiments

2019-06-04

Abstract excerpt

Advances in fluorescence microscopy have introduced new assays to quantify live-cell translation dynamics at single-RNA resolution. We introduce a detailed, yet efficient sequence-based stochastic model that generates realistic synthetic data for several such assays, including Fluorescence Correlation Spectroscopy (FCS), ribosome Run-Off Assays (ROA) after Harringtonine application, and Fluorescence Recovery After...

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Literature Corpus work: 50f5dedb-2bfb-5010-8bbf-cb5077c1122e
DOI: 10.1101/659987

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