Article

Genomic sequences and RNA binding proteins predict RNA splicing kinetics in various single-cell contexts

2021-05-02

Abstract excerpt

RNA splicing is a key step of gene expression in higher organisms. Accurate quantification of the two-step splicing kinetics is of high interests not only for understanding the regulatory machinery, but also for estimating the RNA velocity in single cells. However, the kinetic rates remain poorly understood due to the intrinsic low content of unspliced RNAs and its stochasticity across contexts. Here, we estimated...

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Literature Corpus work: f6642e4b-9305-59af-9380-9a1812970de0
DOI: 10.1101/2021.05.02.442314

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