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Article

"Nought may endure but mutability": spliceosome dynamics and the regulation of splicing.

Molecular cell - 20 Jun 2008

Smith Duncan J, Query Charles C, Konarska Maria M

Abstract excerpt

The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.

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Identifiers

PMID: 18570869
DOI: 10.1016/j.molcel.2008.04.013
PMCID: PMC2610350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18570869-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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