Article

Human co-transcriptional splicing kinetics and coordination revealed by direct nascent RNA sequencing

2019-04-16

Abstract excerpt

Human genes have numerous exons that are differentially spliced within pre-mRNA. Understanding how multiple splicing events are coordinated across nascent transcripts requires quantitative analyses of transient RNA processing events in living cells. We developed nanopore analysis of CO-transcriptional Processing (nano-COP), in which nascent RNAs are directly sequenced through nanopores, exposing the dynamics and p...

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Literature Corpus work: 1e910118-7e84-5390-97c2-2bcbaf13ac46
DOI: 10.1101/611020

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