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Article

Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate.

Genes & development - 1 Dec 2014

Fong Nova, Kim Hyunmin, Zhou Yu, Ji Xiong, Qiu Jinsong, Saldi Tassa, Diener Katrina, Jones Ken, Fu Xiang-Dong, Bentley David L

Abstract excerpt

Alternative splicing modulates expression of most human genes. The kinetic model of cotranscriptional splicing suggests that slow elongation expands and that fast elongation compresses the "window of opportunity" for recognition of upstream splice sites, thereby increasing or decreasing inclusion of alternative exons. We tested the model using RNA polymerase II mutants that change average elongation rates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25452276
DOI: 10.1101/gad.252106.114
PMCID: PMC4248296

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